Dialysis
Haemodialysis
      
Definition
o        Hemodialysis is a process to remove fluid and waste products from the body and blood when the kidneys cannot do so.

o     May also be used for
       oedema
       hepatic coma,
       hyperkalemia,
       hypercalcemia,
       hypertension
       uremia

o        Dialyzer - serves as a synthetic semipermeable membrane replacing renal glomeruli and tubules.

o        Treatement for 3 - 4 hours 3 - 4 times a week

o        Or - short daily haemodialysis

Principle of Dialysis
o        Dialysis works on the principle of diffusion of solutes across a semipermeable membrane - osmosis
o        Smaller solutes pass through the membrane.
o        The concentrations of undesired solutes (for example potassium, urea, and phosphorus) are high in the blood, but low or absent in the dialysis solution.
o         The dialysis solution is isotonic for sodium and chloride.
o        For bicarbonate, dialysis solution level is set at a slightly higher level than in normal blood, to encourage diffusion of bicarbonate into the blood, to neutralise the acidosis that is often present in these patients.

        Indications
-         volume overload
-        electrolyte imbalance
-        uremic symptons

       Contraindications/disadvantages
-        Hemodynamic instability
-        vascular access problems
-        hepatitis
-        muscle cramping
-        bleeding tendencies due to anticoagulant used

       Types of vascular access
-        Temporary double or single lumen catheters
-        AV fistulas
-        grafts (Gortex)
-        shunts (Scribner)

       Vascular Access
o        The rate of flow should be 200 to 800 ml / mt.
o        Subclavian, internal jugular, and femoral catheters
o        Double or multilumen catheters
o        Fistula - AV fistula - created by surgery -  between the cephalic vein and the radial artery -  near the wrist - fistula takes 4 - 6 weeks to mature
      Graft
o        An arteriovenous graft created - synthetic graft made of PTFE = polytetrafluoroethylene
o        Fore arm, upper arm, upper thigh
o        For patients who don't have suitable vessels
o        Complications - infection, thrombosis

       Complications and problems during dialysis
o        Disturbances of lipid metabolism
o        Fluid overload
o        Heart failure, CAD, anginal pain
o        Stroke
o        Anemia and fatigue
o        Gastric ulcers - due to physiological stress
o        Renal osteodystrophy that produces bone pain and fractures
o        Malnutrition
o        Infection
o        Neuropathy and pruritus

o        Hypotension
o        Painful muscle cramping
o        Exsanguination accidental
o        Dysrhythmias
o        Air embolism
o        Chest pain


Types of continuous renal relacement therapy
o        Cotinuous arteriovenous haemofiltration - for fluid overload
o        Continuous arteriovenous haemodialysis - faster clearance of urea
o        Continuous venovenous haemofiltration - double-lumen catheter - acute renal failure
o        Continuous venovenous haemodialysis

Peritoneal Dialysis
       is dialysis using the peritoneum as the dialyzer - the semipermeable membrane

       Indications :
o        Those who are unwilling to undergo haemodialysis
o        Diabetes mellitus
o        Cardiovascular disease
o        Elderly patients
o        Risk of heparin
o        Severe hypertension
o        Heart failure
o        Pulmonary oedema

       Peritoneal - approaches
o        Acute intermittent peritoneal dialysis
o        Continuous ambulatory peritoneal dialysis (CAPD)
o        Continuous cyclic peritoneal dialysis (CCPD)

       Underlying principles
o        Peritoneum - a serous membrane - used as the semipermeable membrane - 22000 cm2
o        Sterile dialysate introduced into the peritoneal cavity at intervals through an abdominal catheter at intervals
o        Urea and creatinine and other metabolic end-products normally excreted by the kidneys are cleared from the blood by diffusion and osmosis

       Procedure
o        Explain
o        Record baseline vital signs, weight, electrolytes level
o        Empty bladder and bowel to avoid injury
o        Prophylactic antibiotics

Preparing the equipment
o        Assemble the equipment
o        Decide concentration of the dialysate
o        Antibiotics and heparin added
o        Aseptic precautions
o        Warm up the solution
o        Avoid air in the tubing

Inserting the catheter
o        At OT - preferable
o        A rigid stylet catheter for acute dialysis only
o        Skin painted with antiseptics
o        Local anaesthesia
o        Stab wound 3 - 5 cm below the umbilicus
o        Trocar inserted, catheter inserted, trocar removed and catheter is secured to the abdominal wall by a purse string suture.
o        Catheter - silicone - radio-opaque

Performing the exchange
o        A series of exchanges or cycles - infusion, dwell and drainage
o        Infused by gravity
o        2 litres over 5 - 10 mts
o        Dwell time varies - 1 to 3 hours

Complications of peritoneal dialysis
o        Peritonitis
o        Leakage
o        Bleeding
Long term complications
o        Hypertriglyceridemia
o        Abdominal hernias
o        Low back pain
o        Clots in the peritoneal catheter
o        constipation

       Types of Peritoneal dialysis
o        Acute Intermittent Peritoneal Dialysis
o        Continuous Ambulatory Peritoneal Dialysis
o        Continuous Cyclic Peritoneal Dialysis

       Nursing Management
o        Protect the vascular access
       The limb is not used to measure BP
       No blood specimens from that limb
       Avoid tight dressings, jewellery
       The bruit or thrill monitored to detect block
      
o        Meet psychosocial needs
o        Promote home and community based care
o        Teach patients self-care
o        Teach patients about haemodialysis
o        Educate about continuing care

o        Take precautions during intravenous therapy - strict volume control - use volumetric infusion pumps
o        Monitor symptoms of uremia
o        Detect cardiac and respiratory complications - fluid overload - heart failure - pulmonary oedema - pericarditis - pericardial effusion
o        Control electrolyte levels and diet
o        Manage discomfort and pain
o        Monitor blood pressure
o        Prevent infection
o        Care for catheter site
o        Administer medications
o        Provide psychological support






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