Doxycycline

Definition
A broad spectrum Antibiotic - belongs to tetracyclines group
For certain bacteria and protozoa
Mainly for tuberculosis
Prophylactic in people exposed to Haemophilus influenza type b and meningococcal disease

Uses
Used in bacterial pneumonia, acne, chlamydia infections, Lyme disease, cholera and syphilis
used with quinine for treatment of malaria and its prevention
Chronic prostatitis, sinusitis, pelvic inflammatory disease,
Rickettsial infections
Rocky Mountain Spotted Fever
Bubonic plague
Anthrax
Nongonococcal urethritis

Bacterial Spectrum
Mycoplasma pneumoniae
Lymphogranuloma venereum (LGV)
Trachoma virus ????
Chlamydia psittaci (ornithosis)
Borrelia recurrentis (relapsing fever)
Hemophilus ducreyiChancroid
Chlamydia trachomatis (Trachoma)


Adverse Effects
Diarrhea
Nausea & vomiting
Red rash
Sunburn
If used in pregnancy or in young children leads to staining of the teeth
Interactions
Reduces the effect of oral contraceptives
Antagonistic to the microbiologic effects of gentamycin and amikacin

Mechanism of Action
Inhibits DNA dependent RNA synthesis

Pharmokinetics
Absorbed easily from the GIT




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