Frusemide

Definition
Frusemide/Furosemide/Lasix
Loop Diuretic
Effect on Loop of Henle
High-ceiling diuretic

Indications
Acute heart failure
Acute pulmonary edema
Edema of Heart failure,renal disease, liver disease
Hypertension
When need rapid action

Caution
Children : not > 6 mg/kg/d
May aggravate fluid loss in vomiting, diarrhoea, profuse sweating
Pregnancy : avoid if possible
Lactation : passes on to the baby
Elderly : lowest possible dose used. dose gradually titrated up. monitor electrolytes

Method of administration
Oras : Tablets  Onset of action : 1 hour
IM/IV injection Onset of action 5 min

Side Effects
Postural hypotension
Electrolyte abnormalities
Hearing loss

Interactions
Synergism with antihypertensives
NSAID - increased nephrotoxicity
Digoxin - enhances digitoxicity
Aminoglycosides - increased ototoxicity

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