First Semester
(Modified Regulation)

     Select the most appropriate response.

1. Streptmycin sulphate is not absorbed orally because it is
  1. Degraded by gastrointestinal enzymes
  2. Destroyed by gastric acid
  3. Highly ionized at a wide range of pH values
  4. Insoluble in water

2.   The aminoglycoside antibiotic which is distinguished by its resistance to bacterial aminoglycoside inactivating enzyme is
  1. Kanamycin
  2. Sisomycin
  3. Amikacin
  4. Tobramycin

3.   An aminoglycoside antibiotic should not be used concurrently with the following drugs
  1. Ampicillin
  2. Vancomycin
  3. Ciprofloxacin
  4. Rifampicin

4.    All of the following statements regarding pentamidine isethionate are true except
  1. It is indicated for threatment or prophylaxis of infection due to Pneumocystis carini
  2. It may be administered intramuscularily, intravenously or by inhalation
  3. It has no clinically significant effect on serum glycose
  4. It is effective in the treatment of leishmaniasis

5.   Prolonged oral therapy with the following antibiotic can damage intestinal villi resulting in steatorrhoea and loose motions
  1. Ampicillin
  2. Tetracycline
  3. Neomycin
  4. Nystatin

6.    Hepatitis with cholestatic jaundice occurs most frequently as an adverse reaction to the following preparation of erythromycin
  1. Erythromycin base
  2. Erythromycin stearate
  3. Erythromycin estolate
  4. Erythromycin ethylsuccinate

7.   The following antibiotic is a first line drug for tratment of Mycobacterium avium complex infection in AIDS patients
  1. Clindamycin
  2. Clarithromycin
  3. Roxithromycin
  4. Erythromycin

8.   Roxithromycin has the following advantages over erythromycin except
  1. It is more effective in whooping cough
  2. It causes less gastric irritation
  3. It has longer plasma half-life
  4. It is unlikely to precipitate theophylline toxicity

9.    The highest incidence of antibiotic associated pseudo membranous enterocolitis has been noted with the use of
  1. Ampicillin
  2. Chloramphenicol
  3. vancomycin
  4. Clindamcin

10. The drug of choice for treatment of methicillin resistant Staphylococcus aureus infection is
  1. Cloxacillin
  2. Vancomycin
  3. Erythromycin
  4. Amikacin

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