Pethidine

Definition
Pethidine/Meperidine/Demerol
Synthetic opioid of phenylpiperidine class
Pain relieving drug for moderate or severe pain

Indications
Labour and delivery
Diverticulitis
Postanesthetic shivering
Any severe pain

Caution
Addiction forming
Euphoria
Difficulty in concentrating
Difficulty in cognitive performance

Method of administration
Oral : Tablets  Onset of action : 1 hour
IM/IV/SC injection Onset of action 5 min
Duration of effect 120 -150 mts

Side Effects
Nausea
Vomiting
Sedation
Giddiness
Diaphoresis
urinary retention
Constipation
Respiratory depression
Muscle faccidity
Hypotension

Mechanism of Action
Acts as an agonist at the µ opioid receptor

Pharmacokinetics
Hydolysed in the liver to pethidinic acid and also demethylated to  norpethidine
Excreted in the urine

Interactions
MAO inhibitors -serious interactions
Muscle relaxants
Ethanol
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